(1) Because of incidences of nephrotoxicity when taken over long periods, phenacetin is no longer available in the U.S. Found in two products.(2) Abuse of combination analgesics containing phenacetin , antipyrine (phenazone) and caffeine have been associated with urinary tract tumors.(3) I have seen several patients come to our emergency room over the years in acute renal failure induced by Ibuprofen, Motrin, Aspirin, phenacetin , and other anti-inflammatory drugs.(4) Phenacetin was used as an analgesic and antipyretic drug until 1983 when it was removed from the market because it can induce nephropathy and cancer.
