(1) Protein losses in sweat, protein hidrosis , also occur as a result of exercise.(2) Fewer than 6 percent of patients had severe compensatory hidrosis , and the recurrence rate was 3 percent.(3) Patients presenting with palmar-plantar hidrosis deserve a trial of all conservative treatments including iontophoresis before more aggressive techniques such as botulinum toxin are tried.(4) In the hidrotic form of ED, the sweat glands function improperly.(5) Clouston syndrome (or hidrotic ectodermal dysplasia) is a rare disease that affects one in 100 000 subjects.(6) Clouston syndrome is an hidrotic form of ectodermal dysplasia, inherited as an autosomal dominant trait with high penetrance.