(1) In addition to histones, some HATs can acetylate non-histone proteins, suggesting multiple roles for these enzymes.(2) The acetylation of salicylic acid increased the potency of morphine by making the compound more soluble in brain fat and facilitating transfer across the blood brain barrier.(3) This effect is consistent with the expected large reduction in electron density on the amino nitrogen upon acetylation thus making coordination with copper much less strong.(4) Slowly, as researchers learned more about the structure of histones, it became evident that patterns of acetylation and methylation could be quite precise.(5) From a dynamic point of view, histone-tail modifications, such as acetylation , phosphorylation, or methylation, are necessary to allow the activity of the chromatin remodeling complex.(6) Serotonin in this gland is acetylated , then methylated, forming melatonin.(7) Histones (DNA packaging proteins) have lysine tails, which can be acetylated in a post-translational modification step.(8) The proteins became acetylated instead, preventing glucose from attaching.(9) Important mechanisms for epigenetic alteration of gene expression include DNA methylation and histone acetylation .(10) The N-terminal group was acetylated to reproduce the experimental conditions at which the protein was studied.
