(1) If we turn now to the liposomal membrane, a gradient of solvent polarity is expected within the bilayer, increasing as one goes from deep within the lipophilic bilayer out toward the aqueous phase.(2) The lipophilic part inserts into one or both leaflets of the lipid membrane and can consist of phospholipids, cholesterols, alkyl chains or phytanyl groups.(3) In the presence of lipophilic carrier proteins the removal is accelerated.(4) Due to its lipophilic nature, vitamin E accumulates in cellular membranes, fat deposits and other circulating lipoproteins.(5) Cholesterol, which is far more lipophilic than the hormones, associates tightly with the bilayer and does not cross it at all.
