(1) Furthermore, children with humoral immunodeficiencies often have infections in other sites such as ears, lung, and skin.(2) In humoral physiology a good fever was seen to eliminate impurities from the body and clarify all the humours.(3) In ancient Greek history, bloodletting was practiced according to the humoral theory, which proposed that when the four humors, blood, phlegm, black and yellow bile in the human body were in balance, good health was guaranteed.(4) The humoral vision of the body lasted until the late seventeenth century in Europe.(5) Both humoral and cell-mediated immune mechanisms influence the outcome of the infection.(6) Greek medicine had understood gout as a humoral disease.(7) Holistic medicine, which for centuries had been associated with the humours, still exists - though largely bereft of humoral theory - as alternative medicine.(8) Ancient Galenic expositions of the body's humoral composition, and attendant physical fluctuations, further complicated a woman's position.(9) Patients with humoral primary immunodeficiencies have an intact cellular immune system; thus, they are able to handle most viral and fungal pathogens, a factor that can help to distinguish these disorders clinically.(10) Therefore, they may fail to elicit a humoral immune response.(11) Still, some cell-mediated and humoral immune system responses may be slightly impaired by heavy marijuana use.
