(1) The disease responds to erythromycin or tetracycline and similar drugs.(2) Treatment is with antibiotics such as erythromycin and tetracycline.(3) The most frequently used topical antibiotics are clindamycin and erythromycin .(4) In its early stages, leptospirosis can be treated with antibiotics such as penicillin, streptomycin, tetracycline and erythromycin .(5) This strain was resistant to methicillin, cephalothin, gentamicin, erythromycin , chloramphenicol and tetracycline.